Acupuncture for mild cognitive impairment leukoaraiosis impact of functional magnetic resonance

Title: Acupuncture for mild cognitive impairment leukoaraiosis impact of functional magnetic resonance Author: Hou Xiaobing Degree-granting units: Beijing University of Chinese Medicine Keywords: Acupuncture;; leukoaraiosis;; mild cognitive impairment;; functional magnetic resonance imaging;; magnetic resonance spectroscopy Abstract:
Vascular cognitive impairment refers to vascular risk factors lead to a variety of levels and types of cognitive impairment, covering vascular mild cognitive impairment, vascular dementia and mixed dementia. Early detection, early diagnosis, early intervention vascular Neodymium Magnets mild cognitive impairment can prevent or delay the occurrence and progress of dementia, dementia This lack of effective and economical treatment today, has an extremely important social, economic and medical value.
Mild cognitive impairment leading to vascular heterogeneity factors, including leukoaraiosis, cerebral arteriosclerosis, stenosis, cerebral infarction, cerebral hemorrhage, hypertension, diabetes and so on. Magnetic resonance technology, leukoaraiosis found in the general prevalence of older people, which amounts to 49.7%, its prevalence increased with increasing age, more than 80 years of age is almost 100%. Leukoaraiosis more than just a pathological image changes, it is important that the clinical manifestations were cognitive impairment, cognitive impairment so both imaging and pathological changes of leukoaraiosis on a mild vascular cognitive barriers to a good starting point.
Acupuncture is the treatment of dementia, a more effective method, clinical focusing mostly in a variety of neuropsychological scale evaluation of the efficacy of acupuncture, not from the cognitive point of view of neuroimaging to explore the mechanism of acupuncture and efficacy of objective criteria. Functional magnetic resonance technology is an important class of medical data visualization technology, which can function in the human brain and objective information visualization display. Thus, functional magnetic resonance technology to study acupuncture intervention mechanism of action of mild cognitive impairment and efficacy of objective criteria providing advanced methods and means.
In this experiment, mild cognitive impairment as leukoaraiosis study, functional magnetic resonance imaging as a research tool, refer to the actual clinical situation, long-range acupuncture intervention, through neuropsychological evaluation of leukoaraiosis scale mild cognitive impairment The clinical changes observed on this basis before and after acupuncture leukoaraiosis mild cognitive impairment of brain function and brain MRI changes in neurotransmitters, acupuncture http://www.everbeenmagnet.com/en/products/110-sintered-neodymium-magnets
 intervention to explore the mechanism of mild cognitive impairment and efficacy of the objective of standards.
Papers, including literature review and clinical studies two parts.
Literature Review section
Summarizes the acupuncture treatment of vascular cognitive impairment ancient literature on the clinical and basic research in relevant content, reviewed brain magnetic resonance imaging in mild cognitive impairment and application of acupuncture research, analysis of domestic and foreign Research and problems, proposed future development.
Part of clinical trials
Acupuncture for mild cognitive impairment leukoaraiosis functional magnetic resonance effects. Mild cognitive impairment observed leukoaraiosis acupuncture intervention before and after the fMRI brain neurotransmitter changes and the situation.
Into LAMCI subjects in 23 cases, normal subjects (control group) in 13 cases. LAMCI were tested further for the acupuncture group of 10 patients stratified with the natural process of group 13 cases, the acupuncture group treatment for 3 months, the natural process of group dynamics for 3 months, into the group that day, three months after treatment, neuropsychological evaluation , functional magnetic resonance imaging and spectroscopy MRI; the control group into the group the same day as neuropsychological assessment, functional magnetic resonance imaging and spectroscopy MRI. MMSE and neuropsychological evaluation for the MoCA evaluation, MRI spectroscopy NAA / Cr, Cho / Cr, MI / Cr.
Results:
1. Cingulate gyrus in the back, LAMCI subjects and normal subjects of NAA / Cr, Cho / Cr, MI / Cr was no significant difference;
(2) to match the age correction factors, the selected eight cases LAMCI were tested with normal subjects comparison of neurotransmitter re-found two groups of NAA / Cr, Cho / Cr was no significant difference, LAMCI subjects group MI / Cr increased significantly, the two groups were significantly different;
3 of 5 patients LAMCI were tested acupuncture intervention for three months, before acupuncture abnormal neuropsychological score, neuropsychological score after acupuncture normal. Acupuncture intervention group and the natural process of group LAMCI were tested between NAA / Cr, Cho / Cr, MI / Cr was no significant difference;
4 hearing before acupuncture music tasks activated brain areas including the temporal lobe of the superior temporal gyrus (BA22), temporal gyrus (BA21), temporal poles (BA38); frontal somatosensory cortex (BA1) and premotor cortex (BA6), acupuncture activates the brain's temporal lobe, including superior temporal gyrus (BA22); the amount of orbital frontal lobe (BA11), frontal pole region (BA10), frontal lobe was covered. Activated brain areas are activated before acupuncture was significantly less than the area.
Conclusion:
1. Leukoaraiosis mild cognitive impairment damaged brain functional areas involved in frontal temporal lobe, the performance of tasks for the implementation of the temporal lobe auditory cortex activation increased, the prefrontal cortex is not activated. Functional magnetic resonance imaging diagnosis for mild cognitive impairment, to determine efficacy and the mechanism of acupuncture provides a visual basis.
2. Leukoaraiosis cingulate mild cognitive impairment occurred at neurotransmitter changes, the performance of MI / Cr ratio increased, the disease may be one of objective diagnostic criteria.
3. Acupuncture can be used as leukoaraiosis mild cognitive impairment is one of effective interventions to reduce the activation of brain areas, to improve the task stimulus processing efficiency, but in order to affect the brain neurotransmitter changes take longer to intervention. Degree Year: 2009